Zhenling Zeng, Ph.D, Male，was born in Xingning City, Guangdong Province in April 196，the Secondary Professor in South China Agricultural University. 

Zhenling Zeng has been cultivated by “Thousand-Hundred-Ten” Program of Guangdong Province. He also has been a member of the State Council’s veterinary professional degree education steering committee, the Ministry of Education's College of Animal Health Professional Teaching Steering Committee and the Director of the Veterinary Pharmacology and Toxicology Branch of the Chinese Academy of Animal Husbandry and Veterinary Medicine Society.

Zhenling Zeng is the chairman of National Reference Laboratory of Veterinary Drug Residues, the director of National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drug, Key Laboratory of Veterinary Drug Development and Safety Evaluation of Guangdong Province and Guangdong University College of Veterinary Drug Innovation Engineering Technology Research Center. He is also the Vice Chairman of the Veterinary Pharmacology and Toxicology Branch of the Chinese Association of Animal Husbandry and Veterinary Medicine, the Animal Toxicology Branch of the Chinese Animal Husbandry and Veterinary Society and the Division of Veterinary Toxicology of the Chinese Society of Toxicology. He is a member of the first expert group on quality and safety of agricultural products, the first National Food Safety Standards Review Committee and the Fourth and Fifth Chinese Veterinary Pharmacopoeia and the Executive Committee and also a member of the second and third Ministry of Agriculture's veterinary drug residue expert committee.

He has been engaged in veterinary pharmacology and toxicology research for more than 20 years. He has conducted a series of research work on veterinary pharmacokinetics, safety evaluation of new veterinary drugs, animal-derived food safety, veterinary drug residues and bacterial resistance mechanisms. The research results have published more than 100 SCI papers, and the cumulative impact factor has exceeded 250 and has been cited more than 1,000 times. He published 10 books about monographs, textbooks and popular science. More than 20 invention patents have been authorized and 3 national veterinary drug certificates have been issued.

He has been awarded Outstanding Ph.D. of Guangdong Province, National Candidate of Thousand-Hundred-Ten” Program in Colleges and Universities of Guangdong Province, Outstanding Teacher in Nanyue, Guiding Teacher of Excellent Doctoral Dissertation in Guangdong Province and National Outstanding Dissertation Advisor on Veterinary Master Degree etc. He has won the second prize for national science and technology progress once, the first prize for scientific and technological progress at provincial and ministerial level three times and the second prize once and the third prizes three times. He also won the second prize of national teaching achievement once; the first prize of provincial teaching achievement once and the second prize once; excellent teaching material of national agricultural universities; one national excellent course, one national excellent resource sharing course, one excellent course in Guangdong Province.

Education and training experience：

July 1979~July 1984, the bachelor student, major on veterinary in the Department of Animal Husbandry and Veterinary Medicine of South China Agricultural University. 

September 1984~September 1987, the master student, major on Veterinary Pharmacology and Toxicology in the Department of Veterinary Medicine of South China Agricultural University.

September 1991~June 199，the doctoral student, major on Veterinary Pharmacology and Toxicology in the Department of Veterinary Medicine of South China Agricultural University.

April 2002~April 2003, as a senior visiting scholar in veterinary college of University of Illinois at Champaign-Urbana .

Work experience: 

Since 1987.07, he has been engaged in teaching and research on veterinary pharmacology and toxicology at the Veterinary College of South China Agricultural University. Instructors (1987.07~1990.05), lecturers (1990.06~1993.09), associate professors (1993.10~1997.11), master tutor (1994~), special promotion professor (1997.12~), doctoral tutor (1998~), secondary professor ( 2011.01~).

1998.05~2000.01, Served as deputy director of Department of Veterinary Medicine of South China Agricultural University; 2001.05～2007.01, Served as Dean of Veterinary Collegeof South China Agricultural University; 2000.01~2007.01, Served as Deputy Director of Quality Supervision, Inspection and Testing Center of Livestock and Poultry in Ministry of Agriculture (Guangzhou); 

2007.01~2015.06, Served as Deputy Director of Product Quality Supervision, Inspection and Testing Center (Guangzhou) of Livestock and Poultry in Ministry of Agriculture. 2007.01~now, Director of the National Standards Laboratory for Veterinary Drug Residues (SCAU), Director of the National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory (SCAU), Director of the Key Laboratory of Veterinary Drug Development and Safety Assessment in Guangdong Province, Director of Veterinary Drug Innovation Engineering Research Center of Guangdong University , Director of Veterinary Pharmacology Research Office.

Research areas:

·Pharmacokinetics and pharmacodynamics of new veterinary drugs

·Veterinary drug development and safety evaluation

·Veterinary drug residues and animal-derived food safety

·Bacteria resistant to antibiotics

Undertake research projects:

The National Key Basic Research and Development Program (973 Project): Propagation Mechanism and Epidemiology of Important Drug Resistance Genes in Livestock and Poultry Pathogens (2013CB20703), 2013~2017, Host

The National Natural Science Foundation: Research on the vivo and half-body Pharmacokinetic Pharmparacokinetic Model of Malbofloxacin and Cefquinome (31372480), 2014–2017, Participate

The Ministry of Agriculture: Veterinary Drug Safety Supervision and Risk Assessment (Agricultural Financial Development 2013, 2014, 2015) 2014~2016, Participate

The Ministry of Education: “Innovation Team Development Plan” ,  Research on the Safety Evaluation of Veterinary Antimicrobial Agents, 2014–2016, participated

Guangdong Natural Science Research Team Project: Research on Mechanism of Drug Resistance, Prevention and Control of Important Pathogens of Livestock and Poultry, 2014~2017,

Representative works: (* Corresponding author)

[1] W. Xiong, M. Wang, J. Dai, Y. Sun, Z. Zeng*, Application of manure containing tetracyclines slowed down the dissipation of tet resistance genes and caused changes in the composition of soil bacteria, Ecotoxicology and environmental safety, 147 (2018) 455-460.

[2] D. Zeng, Z. Lin, B. Fang, M. Li, R. Gehring, J.E. Riviere, Z. Zeng*, Pharmacokinetics of Mequindox and Its Marker Residue 1,4-Bisdesoxymequindox in Swine Following Multiple Oral Gavage and Intramuscular Administration: An Experimental Study Coupled with Population Physiologically Based Pharmacokinetic Modeling, Journal of agricultural and food chemistry, 65 (2017) 5768-5777.

[3] M. Wang, Y. Sun, P. Liu, J. Sun, Q. Zhou, W. Xiong, Z. Zeng*, Fate of antimicrobial resistance genes in response to application of poultry and swine manure in simulated manure-soil microcosms and manure-pond microcosms, Environmental Science and Pollution Research, 24 (2017) 20949-20958.

[4] J. Guo, E.W. Chan, S. Chen, Z. Zeng*, Development of a Novel Quantum Dots and Graphene Oxide Based FRET Assay for Rapid Detection of invA Gene of Salmonella, Frontiers in microbiology, 8 (2017) 8.

[20] D. He, L. Liu, B. Guo, S. Wu, X. Chen, J. Wang, Z. Zeng*, J.H. Liu, Chromosomal location of the fosA3 and blaCTX-M genes in Proteus mirabilis and clonal spread of Escherichia coli ST117 carrying fosA3-positive IncHI2/ST3 or F2:A-:B- plasmids in a chicken farm, International journal of antimicrobial agents, 49 (2017) 443-448.

[5] X. Huang, L. Yu, X. Chen, C. Zhi, X. Yao, Y. Liu, S. Wu, Z. Guo, L. Yi, Z. Zeng*, J.H. Liu, High Prevalence of Colistin Resistance and mcr-1 Gene in Escherichia coli Isolated from Food Animals in China, Frontiers in microbiology, 8 (2017) 562.

[6] J. Wang, X. Yao, J. Luo, L. Lv, Z. Zeng*, J.H. Liu, Emergence of Escherichia coli co-producing NDM-1 and KPC-2 carbapenemases from a retail vegetable, China, The Journal of antimicrobial chemotherapy, (2017).

[7] L. Yi, J. Wang, Y. Gao, Y. Liu, Y. Doi, R. Wu, Z. Zeng, Z*. Liang, J.H. Liu, mcr-1-Harboring Salmonella enterica Serovar Typhimurium Sequence Type 34 in Pigs, China, Emerging infectious diseases, 23 (2017) 291-295.

[8] Y. Li, Y. Zhang, H. Ding, X. Mei, W. Liu, J. Zeng, Z. Zeng*, In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin, BMC veterinary research, 12 (2016) 250.

[9] W. Xiong, Y. Sun, X. Ding, M. Wang, Z. Zeng*, Selective pressure of antibiotics on ARGs and bacterial communities in manure-polluted freshwater-sediment microcosms, Frontiers in microbiology, 6 (2015) 194.

[10] W. Xiong, Y. Sun, X. Ding, Y. Zhang, X. Zhong, W. Liang, Z. Zeng*, Responses of plasmid-mediated quinolone resistance genes and bacterial taxa to (fluoro)quinolones-containing manure in arable soil, Chemosphere, 119 (2015) 473-478.

[11] W. Xiong, Y. Sun, T. Zhang, X. Ding, Y. Li, M. Wang, Z. Zeng*, Antibiotics, Antibiotic Resistance Genes, and Bacterial Community Composition in Fresh Water Aquaculture Environment in China, Microbial ecology, (2015).

[12] C. Cao, Y. Qu, M. Sun, Z. Qiu, X. Huang, B. Huai, Y. Lu, Z. Zeng*, In vivo antimicrobial activity of marbofloxacin against Pasteurella multocida in a tissue cage model in calves, Frontiers in microbiology, 6 (2015) 759.

[13] D. He, J. Chiou, Z. Zeng, L. Liu, X. Chen, L. Zeng, E.W. Chan, J.H. Liu, S. Chen, Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid beta-Lactamases Derived from CTX-M-14 and CTX-M-15, Antimicrobial agents and chemotherapy, 59 (2015) 5976-5983.

[14] F. Yang, J. Kang, F. Yang, Z. Zhao, T. Kong, Z. Zeng*, Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats, Journal of Veterinary Science, 16 (2015) 157.

[15] L. Liu, D. He, L. Lv, W. Liu, X. Chen, Z. Zeng, S.R. Partridge, J.H. Liu, blaCTX-M-1/9/1 Hybrid Genes May Have Been Generated from blaCTX-M-15 on an IncI2 Plasmid, Antimicrobial agents and chemotherapy, 59 (2015) 4464-4470.

[16] Y. Qu, Z. Qiu, C. Cao, Y. Lu, M. Sun, C. Liang, Z. Zeng*, Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model, BMC veterinary research, 11 (2015) 294.

[17] Q. Shan, C. Liang, J. Wang, J. Li, Z. Zeng*, In vivo activity of cefquinome against Escherichia coli in the thighs of neutropenic mice, Antimicrobial agents and chemotherapy, 58 (2014) 5943-5946.

[18] J. Wang, Q. Shan, H. Ding, C. Liang, Z. Zeng*, Pharmacodynamics of cefquinome in a neutropenic mouse thigh model of Staphylococcus aureus infection, Antimicrobial agents and chemotherapy, 58 (2014) 3008-3012.

[19]Yang, F., Li, Z.L., Shan, Q., Zeng., Z.L*. Pharmacokinetics of doxycycline in tilapia (Oreochromis aureus x Oreochromis niloticus) after intravenous and oral administration, Journal of Veterinary Pharmacology and Therapeutics, (2014), 37(4):388-393.

[20] G.H. LI, Q. SHAN, J. WANG, Y.F. LI, Y. GAO, Z.L. ZENG*. Metabolism of Mequindox in Isolated Rat Liver Cells, Journal of Integrative Agriculture, (2014), 13(1), 158-166.

[21] J. Shu, L. He, H. Ding, L. Wang, H. Guo, Y. Gao, E. E. Dzakah, Z. Zeng*. Synthesis of furaltadone metabolite, 3-amino-5-morpholinomethyl-2 oxazolidone (AMOZ) and novel haptens for the development of a sensitive enzyme-linked immunosorbent assay (ELISA), Analytical Methods. (2014), 6(1): 2306-2313.

[22] X.M. Liang, G.F. Guo, X.H. Huang, W.L. Duan, Z.L. Zeng*. Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B, Journal of Surgical Research, (2014), 187(2), 596-604

[23] Z.L. Zeng, H.-. Wei, J. Wang, D.C. Lin, X.Q. Liu, J.H. Liu. High prevalence of cfrproducing Staphylococcus species in retail meat in Guangzhou, China, BMC microbiology, (2014), 14: 151-156.

[24] Liqi Wang,Zhenling Zeng, Xianhui Huang,Yijuan Sua and Limin He. Matrix effects caused by phospholipids in multiresidue analysis for beta-agonists with liquid chromatography- electrospray tandem mass spectrometry, RSC Advances, (2014), 4: 25719-25728.

[25] Shan, Q., Liang, C., Wang, J., Li, J., and Zeng, Z*. In Vivo Activity of Cefquinome against Escherichia coli in the Thighs of Neutropenic Mice. Antimicrobial Agents and Chemotherapy, (2014), 58(10): 5943-5946.

[26] Wang, J., Shan, Q., Ding, H., Liang, C., and Zeng, Z*. Pharmacodynamics of Cefquinome in a Neutropenic Mouse Thigh Model of Staphylococcus aureus Infection. Antimicrobial Agents and Chemotherapy, (2014), 58(6): 3008-3012.

[27] Shan, Q., Yang, F., Wang, J., Ding, H., He, L., and Zeng, Z*.  Pharmacokinetic/pharmacodynamic relationship of cefquinome against Pasteurella multocida in a tissue-cage model in yellow cattle. Journal of Veterinary Pharmacology and Therapeutics, (2014), 37(2):178-185.

[28] Shan, Q., Wang, J., Yang, F., Ding, H., Liang, C., Lv, Z., and Zeng, Z*. Pharmacokinetic/pharmacodynamic relationship of marbofloxacin against Pasteurella multocida in a tissue-cage model in yellow cattle. Journal of Veterinary Pharmacology and Therapeutics, (2014), 37(3): 222-230.

[29]Yang F, Sun N,Sun Y X, Shan Q, Zhao H Y, Zeng  D P, Zeng ZL*. A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation. Journal of Veterinary Pharmacology and Therapeutics, (2013)，36（2）:192-200

[30]Yang, F., G.H. Li, X.B. Meng, L.Q. Wang, X.H. Huang, Q. Shan, D.P. Zeng, H.Z. Ding, and Z.L. Zeng*. Pharmacokinetic interactions of flunixin meglumine and doxycycline in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics, (2013), 36(1): 85-88. 

[31] Yang Fan, Huang Xian-Hui, Li Guang-Hui, Ni Heng-Jia, Zhao Yong-Da, Ding Huan-Zhong, Zeng Zhen-Ling*. Estimating tulathromycin withdrawal time in pigs using a physiologically based pharmacokinetics model, Food Additives & Contaminants: Part A, (2013), 30（7）：1255–1263.

[32]Ma, J., J. Liu, L. Lv, Z. Zong, Y. Sun, H. Zheng, Z. Chen, and Z. Zeng*. Characterization of Extended-Spectrum beta-Lactamase Genes Found among Escherichia coli Isolates from Duck and Environmental Samples Obtained on a Duck Farm. Applied and  Environmental Microbiology, (2012), 78(10): 3668-3673.

[33]Hou, J., X. Huang, Y. Deng, L. He, T. Yang, Z. Zeng, Z. Chen, and J. Liu. Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M beta-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (2012), 56(4): 2135-2138. 

[34]Zeng, D., X. Shen, L. He, H. Ding, Y. Tang, Y. Sun, B. Fang, and Z. Zeng*. Liquid chromatography tandem mass spectrometry for the simultaneous determination of mequindox and its metabolites in porcine tissues. JOURNAL OF SEPARATION SCIENCE, (2012), 35(10-11): 1327-1335

[35]Shan, Q., Y. Liu, L. He, H. Ding, X. Huang, F. Yang, Y. Li, and Z. Zeng*, Metabolism of mequindox and its metabolites identification in chickens using LC-LTQ-Orbitrap mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, (2012), 881-882: 96-106. 

[36]Sun, N., J. Liu, F. Yang, D. Lin, G. Li, Z. Chen, Z. Zeng*, Molecular characterization of the antimicrobial resistance of Riemerella anatipestifer isolated from ducks. VETERINARY MICROBIOLOGY, (2012), 158(3-4): 376-383. 

[37]Li, G., F. Yang, L. He, H. Ding, N. Sun, Y. Liu, Y. Liu, Q. Shan, Y. Li, Z. Zeng*, Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration. RESEARCH IN VETERINARY SCIENCE, (2012), 93(3): 1380-86.

[38]Xi, W., L. He, C. Guo, Q. Cai, Z. Zeng*, Simultaneous determination of amoxicillin and clavulanic acid in dog plasma by high-performance liquid chromatography tandem mass spectrometry. ANALYTICAL LETTERS, (2012), 45(13): 1764-1776. 

[39]Wang, A., H. Ding, Y. Liu, Y. Gao, Z. Zeng*, Single dose pharmacokinetics of terbinafine in cats. JOURNAL OF FELINE MEDICINE AND SURGERY, (2012), 14(8): 540-544. 

[40]Yang, F., H.W. Liu, M. Li, H.Z. Ding, X.H. Huang, Z.L. Zeng*, Use of a Monte Carlo analysis within a physiologically based pharmacokinetic model to predict doxycycline residue withdrawal time in edible tissues in swine. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, (2012), 29(1): 73-84. 

[41]Jiang, H., D. Lue, Z. Chen, X. Wang, J. Chen, Y. Liu, X. Liao, J. Liu, Z. Zeng*, High prevalence and widespread distribution of multi-resistant Escherichia coli isolates in pigs and poultry in China. VETERINARY JOURNAL, (2011), 187(1): 99-103.

[42]Zheng, Y., Y. Liu, H. Guo, L. He, B. Fang, Z. Zeng*, Molecularly imprinted solid-phase extraction for determination of tilmicosin in feed using high performance liquid chromatography. ANALYTICA CHIMICA ACTA, (2011), 690(2): 269-274.

[43]Guo, H., K. Liu, Y. Liu, B. Fang, M. Liu, L. He, Z. Zeng*, Molecularly imprinted solid-phase extraction for the selective determination of valnemulin in feeds with high performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, (2011),  879(2): 181-185. 

[44 ]Zeng, Z., G. Deng, X. Shen, M. Rizwan-Ul-Haq, D. Zeng, H. Ding, Plasma and tissue pharmacokinetics of danofloxacin in healthy and in experimentally infected chickens with Pasteurella multocida. J Vet Pharmacol Ther, (2011), 34(1): 101-104.

[45]Zeng, D., C. Lin, Z. Zeng*, X. Huang, L. He, Multi-Residue Determination of Eight Anabolic Steroids by GC-MS in Muscle Tissues from Pigs. AGRICULTURAL SCIENCES IN CHINA, (2010), 9(2): 306-312. 

[46]DING, H., Y. LI, Z. CHEN, M. RIZWAN-ul-HAQ, Z. ZENG*, Plasma and tissue cage fluid pharmacokinetics of marbofloxacin after intravenous, intramuscular, and oral singledose application in pigs. Journal of Veterinary Pharmacology and Therapeutics, (2010), 33(5): 507-510.

[47]Zeng, Z*., J. Wu, G. Yang, Z. Chen, X. Huang, and H. Ding, Study of colistin depletion in duck tissues after intramuscular and oral administration. J Vet Pharmacol Ther, (2010), 33(4): 408-410